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Press Releases
January 29, 2008 PolyMedix To Present At :
Tuberculosis: Biology, Pathology and Therapy (B3)

Part of the Keystone Symposia Global Health Series
Supported by the Bill & Melinda Gates Foundation

Sunday, January 25, 2009 Keystone Resort Keystone, Colorado
December 10, 2008 POLYMEDIX ANNOUNCES POSITIVE PHASE I CLINICAL DATA WITH PMX-30063 NOVEL ANTIBIOTIC DRUG CANDIDATE

First Ever Clinical Study With A Small Molecule Mimetic Of Host Defense Proteins
December 09, 2008 PolyMedix To Present At HIV DART 2008 on Novel Antimicrobial Compounds for Treatment of Drug Resistant Tuberculosis

December 10, 2008, Wyndham Grand Hotel, Puerto Rico
December 02, 2008 POLYMEDIX APPOINTS NEW VICE PRESIDENT OF BUSINESS DEVELOPMENT
J. Gregory Ford Brings Over Twenty Years of Experience to Management Team
November 07, 2008 PolyMedix’s CEO to Present at Rodman & Renshaw’s Tenth Annual Global Healthcare Conference on November 10, 2008
October 28, 2008 POLYMEDIX TO MAKE MULTIPLE PRESENTATIONS OF NEW ANTIBIOTIC DATA AT THE 48th ANNUAL INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (ICAAC)

Annual Meeting on Behalf of the American Society of Microbiology (ASM) Being Held In Washington D.C., October 25 - 28, 2008

Data to be presented include new data for PolyMedix antibiotic compounds that have demonstrated antimalarial activity and antifungal activity, as well as in vitro and in vivo Staphylococci data on PolyMedix’s Phase I i.v. antibiotic product candidate, PMX-30063

September 29, 2008 PolyMedix Presents Data on Anti-Tuberculosis Activity of its Novel Antibiotic Compounds

New Directions In AIDS Treatment Research Policy and Care Symposium
Held September 26, 2008, in New York City

September 24, 2008 PolyMedix Closes $4.25 Million Private Placement Financing

Financing Follows $15 Million Public Offering Completed in July 2008
September 23, 2008 PolyMedix Initiates Dosing in Phase I Clinical Study of Novel Anticoagulant Antagonist Compound

PMX-60056 Heptagonist Is The Only Reversing Agent for Heparin and Low Molecular Weight Heparins in Clinical Development

PMX-60056 is the Company’s Second Clinical Trial Initiation in the Past Month
August 21, 2008 PolyMedix Initiates Dosing in Phase I Clinical Study of Novel Systemic Antibiotic Compound

PMX-30063 The First and Only Defensin Mimetic Systemic Antibiotic Drug In Human Clinical Trials
August 12, 2008 PolyMedix Has Regulatory Clearance to Initiate Phase I Clinical Study of Novel Anticoagulant Antagonist Compound

PMX-60056 Heptagonist The Only Reversing Agent for Heparin and Low Molecular Weight Heparins in Development
PMX-60056 Milestone the Company’s Second Regulatory Clearance in Three Months

July 31, 2008 PolyMedix Closes $15 Million Registered Equity Financing
July 25, 2008 PolyMedix Appoints Two New Directors - Dr. Richard Bank and Dr. Stefan Loren Join the Board of Directors
May 9, 2008 PolyMedix Receives Regulatory Clearance to Initiate Phase I Clinical Study of Novel Systemic Antibiotic Compound

PMX-30063 The First Defensin Mimetic Systemic Antibiotic Drug Cleared For Human Clinical Trials
April 11, 2008 DR. WILLIAM DEGRADO HONORED WITH THE RALPH F. HIRSCHMANN AWARD IN PEPTIDE CHEMISTRY
February 26, 2008 Data on PolyMedix Antimicrobial Polymers presented at American Society of Microbiology 6th Annual Biodefense and Emerging Diseases Research Meeting
January 30, 2008 PolyMedix Appoints Brian Anderson to Board of Directors

This press release contains forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995 that involve risks, uncertainties and assumptions that could cause PolyMedix’s actual results and experience to differ materially from anticipated results and expectations expressed in these forward looking statements. PolyMedix has in some cases identified forward-looking statements by using words such as “anticipates,” “believes,” “hopes,” “estimates,” “looks,” “expects,” “plans,” “intends,” “goal,” “potential,” “may,” “suggest,” and similar expressions. Among other factors that could cause actual results to differ materially from those expressed in forward-looking statements, PolyMedix’s compounds may not enter or successfully complete clinical testing, or be granted regulatory approval to be sold and marketed in the United States or elsewhere. A more complete description of these risk factors is included in PolyMedix’s filings with the Securities and Exchange Commission. You should not place undue reliance on any forward-looking statements. PolyMedix undertakes no obligation to release publicly the results of any revisions to any such forwardlooking statements that may be made to reflect events or circumstances after the date of this press release or to reflect the occurrence of unanticipated events, except as required by applicable law or regulation.

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